Notify patients never to take in excess of 4,000 milligrams of acetaminophen every day. Recommend individuals to phone their Health care provider if they have taken over the recommended dose.
Inform sufferers that leaving acetaminophen and codeine phosphate tablets unsecured can pose a fatal danger to Some others in the house.
e., a number of copies with the gene for cytochrome P450 isoenzyme 2D6 or high morphine concentrations). Youngsters with snooze apnea may very well be significantly delicate towards the respiratory depressant results of codeine. As a result of risk of life-threatening respiratory depression and Loss of life:
Ahead of taking acetaminophen and codeine phosphate tablets, tell your Health care company For those who have a heritage of: head injuries, seizures liver, kidney, thyroid issues challenges urinating pancreas or gallbladder troubles abuse of street or prescription drugs, Alcoholic beverages addiction, opioid overdose, or psychological health issues Are actually instructed by your healthcare supplier that you are a “swift metabolizer” of particular medicines.
Acetaminophen and codeine phosphate tablets are contraindicated for all youngsters more youthful than twelve years of age (see CONTRAINDICATIONS).
Embryo-Fetal Toxicity Notify woman people of reproductive possible that acetaminophen and codeine phosphate tablets might cause fetal hurt and to tell the prescriber of the recognised or suspected pregnancy (see PRECAUTIONS, Pregnancy).
Abruptly halting read more this medication could bring about withdrawal, particularly if you have utilised it for some time or in significant get more info doses. To avoid withdrawal, your physician may possibly decrease read more your dose bit by bit.
Codeine sulfate was not mutagenic during get more info the in vitro bacterial reverse mutation assay or clastogenic from the in vitro Chinese hamster ovary cell chromosome aberration assay.
This medication has long been prescribed for the present-day issue only. Don't utilize it later on for another ailment Except if your medical doctor directs you to do so. Another medication could possibly be essential in that circumstance.
Sufferers that are extremely-immediate metabolizers of codeine due to a CYP450 2D6 polymorphism, will change codeine a lot more promptly and completely to morphine resulting in unexpectedly higher morphine levels, which may be lifestyle-threatening.
Separately titrate acetaminophen and codeine phosphate tablets into a dose that provides sufficient analgesia and minimizes adverse reactions. Continually reevaluate patients acquiring acetaminophen and codeine phosphate tablets to assess the upkeep of soreness Handle, signals and indications of opioid withdrawal, and various adverse reactions, together with reassessing for the event of habit, abuse, or misuse (see WARNINGS).
The use of acetaminophen and codeine phosphate tablets in clients with acute or extreme bronchial asthma within an unmonitored environment or within the absence of resuscitative equipment is contraindicated.
Someone caring for you should request website emergency clinical focus When you've got sluggish respiration with lengthy pauses, blue colored lips, or When you are not easy to wake up.
Recurrent communication among customers of your healthcare crew, people, and their caregiver/loved ones is significant throughout intervals of adjusting analgesic requirements; if the level of soreness improves following dose stabilization, an try really should be made to identify the source of greater pain just before expanding the dose of discomfort medication.